I had isolated a compound from a natural product and i want to really screen its potential activity.
Can any one share recommendations of protein/enzyme/receptor target (For docking purpose)?
It will be nice if you can share one or more in the list below (but actually also not limited to this list)
protein/enzyme/receptor name/ (it will be very helpful if you share along the PDB code:
1. Antidiabetes
2. Anticholesterol
3. Antioxidant
4. Antipyretic
5. Antihypertensive
6. Anti-inflammatory
7. Each type of cancer
8. Gastritis
9. antileukemic
10. Hyperuricemia
11. Antimicrobial
If you are asking something like "what bacteria are you targeting? Or what mechanism you want to study?" it can be anything. So, you can share basically anything.
@Marko Jeremia
For antidiabetic activity Alpha-glucosidase and amylase are one of the good targets
Hello Marko Jeremia Kalalo
For anticancer one could include targets like kinases, tubulin, cancer stem cells, and vascular targeting agents.
The emergence of super bugs because of irrational use of antimicrobials/antibiotics, spontaneous mutations in microbes, lack of regulatory control and supervision on antibiotic use, has led to the existing serious antimicrobial crisis. One drug target in this category could be ATP synthase enzyme which is used by microbes in generating its energy supply.
In autoimmune diseases like Rheumatoid Arthritis therapies that aimed at decreasing levels of pro-inflammatory cytokines already exist, but some have failed clinically or are having extensive adverse effects. Some novel mechanisms targeting pro-inflammatory cytokine release as well as leukocyte chemotaxis is required.
Best Wishes.
There are many web servers in which you can upload the structure of your compound and it will give you a list of predicted druggable targets.
From this list, you can select the top-ranked proteins/targets and search their relevance to the list of diseases you mentioned.
Here are some web servers:
1. Pharmapper
http://www.lilab-ecust.cn/pharmmapper/
2. Swiss target prediction.
http://www.swisstargetprediction.ch/
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