Dear All,
I performed a compound PK analysis in Dog and Monkey. The PK modeling is based on non-compartment analysis (NCA) and, I found that the compound's t-half time much longer than its mean residence time (MRT).
I was wiondering if anyone also observed this phenomena before and could please give me any suggestion to explain the data.
Thank you so much!
Best,
Tianzhu
Hello Tianzhu Zang,
You did not mention how the drug was administered. If the drug was administered IV and follows one-compartment, then MRT > t1/2. If two compartment occurs there a strong possibility that MRT < t1/2. Several years ago two authors, Sobol E, and Bialer M published a paper pertaining to an equation that is applied to this phenomenon. You can access this paper as follows:
http://www.ncbi.nlm.nih.gov/pubmed/15108218. I hope this helps.
Hi Betram,
Thank you so much for your time to answer my question and share the publication.
Both IV and PO dosing showed the same result (MRT < t1/2) and, I could observe the clear alpha-phase and beta-phase in IV dosing "Concentration-time" curve, which probably indicated the two compartment occurs.
Best regards,
Tianzhu
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