There are a lot to be seen on this topic. But statins can cause hyperglycemia by increasing calcium concentration in the islet cells leading to decrease in insulin release..
The popular cholesterol-lowering drug Lipitor is linked to an increased risk of type 2 diabetes, especially in women.
Lipitor (sold generically as atorvastatin) belongs to a popular class of cholesterol-lowering drugs called statins, which make up a major portion of all prescriptions filled in the United States each year. Lipitor plays a role in that popularity: it was the top-selling prescription drug in 2011, generating $7.7 billion dollars in U.S. sales for manufacturer Pfizer that year. It remains one of the most widely prescribed drugs on the market.
Like all statins, Lipitor helps prevent heart disease and stroke by lowering the level of cholesterol in the blood. Recently, medical researchers uncovered new risks associated with the drug, including an increased risk for Type 2 diabetes.
In 2012, the U.S. Food and Drug Administration (FDA) updated the safety labels for all statins and warned consumers that the drugs may be linked to diabetes. Other studies suggest the risk may be even higher for older women. The FDA’s label revisions also indicated that Lipitor and other statins can cause damage to the livers, muscles and cognitive function of some patients, though reports of these injuries are rare.
How Does Lipitor Cause Diabetes?
Although clinical research on Lipitor and other statins indicates these drugs can increase a patient’s risk for developing diabetes, they shed little light on how the increased risk occurs. Type 2 diabetes occurs when the body fails to properly use or produce insulin, a crucial hormone the body uses to convert food into energy.
Bodies break down the food we eat into sugar, or glucose, which travels throughout the bloodstream. But if insulin isn’t working the way it should, glucose can’t enter the body’s cells to provide them with the energy they need. This causes a spike in blood sugar levels – a problem that can result in serious health complications.
Researchers suspect that taking statins, including Lipitor, impairs the function of special cells in the pancreas that store and release insulin. There is also evidence that statins, like Atorvastatin, can decrease the body’s sensitivity to insulin.
Type 2 Diabetes Complications
People who suffer from Type 2 diabetes are at risk for disabling and sometimes life-threatening complications. Diabetes can cause problems with many important organs, like the heart, eyes, kidneys, nerves and blood vessels.
Complications most often occur in people who do not realize they have Type 2 diabetes, because the symptoms can be easy to ignore. Complications often develop slowly over time. Type 2 diabetes complications include:
Heart disease
Nerve damage (neuropathy)
Kidney damage (nephropathy)
Eye damage
Foot damage
Hearing impairment
Bacterial and fungal infections
Alzheimer’s disease
People who suffer symptoms of Type 2 diabetes – like increased thirst, urination and hunger, weight loss, blurred vision and fatigue – should ask their doctor about screening to avoid the risks of long-term complications.
Women and Lipitor Diabetes Risk
Who is Most at Risk for Diabetes from Statin Use?
Lipitor and Crestor users
Post-menopausal women
Asian and white women
Women with a healthy BMI (non-obese)
One 2012 study published in the Archives of Internal Medicine showed that post-menopausal women who took Lipitor or other statins faced a 48 percent increased risk for developing type 2 diabetes compared to those who did not.
The study, which included 153,840 non-diabetic women between the ages of 50 and 79, considered several other factors also known to increase the risk for diabetes, including advanced age, obesity and lack of physical activity.
Researchers found that the risk for diabetes from statins varied among ethnicities. Asian women carried the highest risk followed by white women and Latinas. African American women experienced the lowest risk. The body mass index (BMI) of the patients also affected diabetes risk. Women with a healthy BMI faced a higher risk than obsess women, who have a BMI higher than 30.
Because women are less likely to suffer a heart attack than men, their statin use is lower historically. That trend changed in recent years. According to the Centers for Disease Control, 36 percent of women between the ages of 64 and 74 and 39 percent of those 75 and older take statins to prevent their first heart attack or a repeat cardiac event. For those age ranges, nearly 50 percent of men are taking statins.
Statins increase blood sugar level, not a lot but enough for diabetic patients. That is a reason why should be prefer Fenofibrat for these patients....
Dear professor Sinha - statins have been shown to be associated with an increase in blood glucose. In type 1 diabetes patients we have estimated that the increase is in the magnitude of 2 mmol/mol: (Diabetes Res Clin Pract. 2016 Jan;111:51-7. doi: 10.1016/j.diabres.2015.10.022. Epub 2015 Oct 21.
Statins are independently associated with increased HbA1c in type 1 diabetes--The Thousand & 1 Study.)
Other corhort studies (N. Sattar, D. Preiss, H.M. Murray, P. Welsh, B.M. Buckley, A.J. de Craen, et al. Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials Lancet, 375 (2010), pp. 735–742) and trials, for instance in type 2 diabetes patients, have found similar results.
This should, however, not discourage doctors from prescribing statins since the benefits outweigh the risks, as recently reviewed. (http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)31357-5/abstract).
Statins like atorvastatin , but not phenofibrate ,may increase insulin resistance and also muscle enzymes as aldolase and creatine kinase. This effect as been studied in postmenopausal women..Patients under treatment for high LDL-Cholesterol plasma concentrations , must be controlled each 3 to 5 months. depending on statin doses.