Recently I am going to do some work on the HBx gene that are widely regarded as an oncogene in HCC.I won't research HBV,but just the fragment for expression of HBx,which doesn't cause hepatitis, I don't know if it requires special attention to the biosafety of the research.
If there are some experts having experience in researching HBx gene,could you give me some advices?
really i do not have the answer. but i were you i will write to bio-safety sector at Sandia laboratory .I think they will help you
Dear Hathama,
It can be argued that evidences on HBx oncogenic potential in humans are still controversial. However, since this protein can immortalize different cell types in vitro and induce tumors in mice I think that it should be handled in biosafety level 2.
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