Most research papers I found only studied its effects on depression and Parkinson's disease rather than its ability to treat hyperpigmentation of the skin.
I am beginning to this that it may be useless to study its effect as a skin lightening injectable peptide.
So is the lack of studies covering this effect because it does not lighten the skin, or because it is common sense that a melanin inhibiting factor will lighten the skin and reduce hyperpigmentation, so no one studied it?
I have very limited fund and lab resources for this research from my institution, so I'm trying to invest them in something that will be ground-breaking.
So does MIF-1 lighten the skin when injected into it? And why isn't there much research papers covering its ability to do so?
Thank you.
As far as I know, MIF was detected in amphibians and fishes to account for the lighten part of those animals (i.e ventral part in frogs), but I think that the existence and role of that factor in mammalian skin is not totally characterized. See Article Integumental Pigmentary Factors of Lower Vertebrates - Model...
What animal are you planning to use for injecting? What is your source of MIF-1.Note: On the other hand, be careful about the term MIF. Macrophage migration inhibitory factor (MIF) has been also related to melanogenesis as this factor shows a pseudo dopachrome tautomerase activity.
Best regards,
Thank you for your response Dr. Frances.
I will inject MIF-1 into hairless mice, both male and female. However, I think that lizards are better in such research, but my university cannot provide them.
Can I mention that melanostatin, or MIF-1, is proven to lighten the skin when applied topically. There are actually products in the market containing this peptide. So it does lighten the skin when applied to it.
In your knowledge, does this mean that an injection will also have the same effect as the topical cream?
Thank you
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