Does internal and external dysbiosis increase the risk of atopic disease?

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Elaine Holmes

There is a recently published review from Thoma which might be useful - and then if you are consif=dering manipulation of the microbiome to mediate the atopia there is an article on synbiosis use which provides a meta-analysis of clinical trials- see below

Thomas CL, Fernández-Peñas P. The microbiome and atopic eczema: More than skin

deep. Australas J Dermatol. 2016 Jan 28. doi: 10.1111/ajd.12435. [Epub ahead of

print] Review. PubMed PMID: 26821151.

Chang YS, Trivedi MK, Jha A, Lin YF, Dimaano L, García-Romero MT. Synbiotics

for Prevention and Treatment of Atopic Dermatitis: A Meta-analysis of Randomized

Clinical Trials. JAMA Pediatr. 2016 Jan 25. doi:

10.1001/jamapediatrics.2015.3943. [Epub ahead of print] PubMed PMID: 26810481.

Patricia Grace-Farfaglia

Zhang, M., Jiang, Z., Li, D., Jiang, D., Wu, Y., Ren, H., . . . Lai, Y. (2015). Oral antibiotic treatment induces skin microbiota dysbiosis and influences wound healing. Microb Ecol, 69(2), 415-421. doi: 10.1007/s00248-014-0504-4

Nakamizo, S., Egawa, G., Honda, T., Nakajima, S., Belkaid, Y., & Kabashima, K. (2015). Commensal bacteria and cutaneous immunity. Semin Immunopathol, 37(1), 73-80. doi: 10.1007/s00281-014-0452-6

Naik, S., Bouladoux, N., Linehan, J. L., Han, S. J., Harrison, O. J., Wilhelm, C., . . . Belkaid, Y. (2015). Commensal-dendritic-cell interaction specifies a unique protective skin immune signature. Nature, 520(7545), 104-108. doi: 10.1038/nature14052

SanMiguel, A., & Grice, E. A. (2015). Interactions between host factors and the skin microbiome. Cell Mol Life Sci, 72(8), 1499-1515. doi: 10.1007/s00018-014-1812-z

Luis Antonio Ochoa-Ramírez

Dermatologic yet not atopic, I share a paper of dysbiosis in vitiligo: