I am using Glycerly oleate with PEG 400 of amount 0.1 mg and 2.5 mg per strips weighing 200 mg contains 78 mg of pullulan but it shows elongation , probably due to over plasticization. What is the solution ?How to reduce elongation
Many fatty esters are used as plasticizers in polymers, with the well known example of PVC, which is heavily loaded by such compounds (stearates, sebacates, adipates, ...). And glycerol is another well known plasticizer. So for sure you have too much plasticizer in your formulation. Adding less of this coumpound, or introducing fillers or a few crosslinkers may limit the problem.
Alain
Glycerly oleate with PEG 400 is much different from glycerol - containing a hydrophobic moiety and PEG.
Pullulan is a polysaccharide only hydrophilic. I would expect that both are at least partly incompatible.
Mr. Titus Sobisch: Well the formulations also contains, about 25 % to 30 % oil phase, pullan just acts as the matrix base . The formulation is prepared by emulsification process using silverson mixer followed by layering and drying. we cannot use glycerol as it rapidly absorbs moisture than the mentioned polymer causing the stickness in the film resulting in product instability.
Mr Alain: Can you give the examples of some fillers or crosslinkers that may be used to limit the problem.
Regards
Hassan
An additive acts as plasticizer if it is soluble in the polymer. To check on this run a DSC analysis and see if addition of the product you expect to be plasticizer lowers the Tg of the polymer...
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