It looks to me that the relationship between anxiety and dementia is much less strong than the one between depressive symptoms and dementia. And that anxiety could be confounded by depression (and vice-versa?).
You may wish to contact Janet Duchek and David Balota at Washington University in St. Louis. They've done some interesting work on neuroticism and dementia (e.g., Duchek et al., 2007, J of Gerontology) that is highly relevant.
Dear Christophe,
May these following papers help you.
Best regards
Hermine
- Paul SM. Anxiety and depression: a common neurobiological
substrate? J Clin Psychiatry. 1988;49 Suppl:13–16.
- Ballard C, Neill D, O’Brien J, McKeith IG, Ince P, Perry R. Anxiety,
depression and psychosis in vascular dementia: prevalence and
associations. J Affect Disord. 2000;59(2):97–106.
- Hiller W, Zaudig M, von Bose M. The overlap between depression and
anxiety on different levels of psychopathology. J Affect Disord. 1989;16(2-3):223–231.
- Beekman AT, de Beurs E, van Balkom AJ, Deeg DJ, van Dyck R, van
Tilburg W. Anxiety and depression in later life: Co-occurrence and
communality of risk factors. Am J Psychiatry. 2000;157(1):89–95.
- de Bruijn RF, Direk N, Mirza SS, et al. Anxiety is not associated with the risk of dementia or cognitive decline: the Rotterdam Study.Am J Geriatr Psychiatry. 2014;22(12):1382-90
- Potvin O, Forget H, Grenier S, Préville M, Hudon C. Anxiety, depression, and 1-year incident cognitive impairment in community-dwelling older adults. J Am Geriatr Soc. 2011;59(8):1421-8.
Hi Christophe
This is a difficult subject as depression in AD seems to have different characteristic from depression in non-AD cases, depression seems to be observed at the early stages of the pathology. Because depression increases neuroinflammation it can perfectly trigger or accelerate the progression of the pathology, what comes first we do not have clear answers. anxiety is higher in the elderly due to changes in stress response and general decrease in synaptic plasticity, we discussed some of this topic in our frontier paper
doi: 10.3389/fnagi.2014.00162
the literature that we cited in this manuscript is cited below
Modrego,P.J.(2010).Depression in Alzheimer’s disease.Pathophysiology,diag-
nosis, and treatment. J. Alzheimers Dis. 21, 1077–1087.doi:10.3233/JAD-2010-
100153
Raudino,F.(2013).Non-cognitivesymptomsandrelatedconditionsinthe
Alzheimer’s disease:aliterature review. Neurol.Sci. 34, 1275–1282.doi:
10.1007/s10072-013-1424-7
Starkstein,S.E.,andMizrahi,R.(2006).Depression in Alzheimer’s disease. Expert.
Rev. Neurother. 6, 887–895.doi:10.1586/14737175.6.6.887
Theleritis,C.,Politis,A.,Siarkos,K.,andLyketsos,C.G.(2013).Areviewof
neuroimaging findings of apathy in Alzheimer’s disease. Int.Psychogeriatr. 26,
195–207. doi:10.1017/S1041610213001725
Vilalta-Franch,J.,Lopez-Pousa,S.,Llinas-Regla,J.,Calvo-Perxas,L.,Merino-
Aguado,J.,andGarre-Olmo,J.(2013).Depression subtypes and 5-year risk
of dementia and Alzheimer disease in patients aged 70years. Int.J.Geriatr.
Psychiatry 28, 341–350.doi:10.1002/gps.3826
Even,C.,and Weintraub,D.(2010).Case for and against specificity of depression in
Alzheimer’s disease. PsychiatryClin.Neurosci. 64, 358–366.doi:10.1111/j.1440-
1819.2010.02108.x
best
Valentina
Depression is certainly a frequent comorbid disorder of dementia, ranging from around 20 to 60% . We did a recent study on the different prevalences in eight European countries, and also the factors associated with gaving depression, one of which was pain, but also the living situation, so either living at home or in a nursing home.
http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=9576232&fileId=S1041610214002610 -- this is the paper in International Psychogeriatrics
Hi Dear Christophe
You can find great information following this link:
http://journals.lww.com/psychosomaticmedicine/Abstract/2009/07000/Does_Anxiety_Affect_Risk_of_Dementia__Findings.11.aspx
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