If such a protein has in fact been synthesized, has it been shown to be crystallizable and amenable to x-ray crystallographic 3D structure determination?
I am not sure about proteins composed of D-amino acids only, but recently it was shown successful for the racemic mixture of L and D- synthesised proteins. See the following paper:
"A functional role of Rv1738 in Mycobacterium tuberculosis persistence suggested by racemic protein crystallography".
https://www.researchgate.net/publication/275221186_A_functional_role_of_Rv1738_in_Mycobacterium_tuberculosis_persistence_suggested_by_racemic_protein_crystallography
Article A functional role of Rv1738 in Mycobacterium tuberculosis pe...
This is an idea that Steve Kent has been very keen on for a number of years. Best to check out his other publications!
D-amino acid proteins were synthesized back in 1992, see link to prior discussion on this topic, 2nd link gives original reference
https://www.researchgate.net/post/Could_it_in_principle_be_possibe_to_engineer_synthesis_whole_proteins_using_only_D-amino_acids_as_opposed_to_the_normal_L-amino_acids
https://www.researchgate.net/deref/http%3A%2F%2Fscience.sciencemag.org%2Fcontent%2F256%2F5062%2F1445.full.pdf%2Bhtml
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