I'm fairly new to cancer research and there's a host of articles on Sunitinib being administered via oral gavage in mice models but I'm unable to find any information on studies that have explored directly injecting tumors with Sunitinib. Just curious.
Hello Paul
Yes, you are right. Good thought. Why not inject drug directly into the tumour? This will reduce major side effects including destruction of healthy cells. You can refer to the article in Science Daily dated 23May 2017. The scientific community has been trying this as well.
The tumour is heterogeneous in nature. It has a central necrotic region which lacks vasculature and therefore deficient in oxygen and nutrients. Also within the tumour differences exist in pH and blood supply in addition to intra-tumoral pressure.
All these factors have to be taken into consideration when injecting drug directly into the tumour.
Regards.
I appreciate the quick and informative response Malcolm Nobre . What's the name of that article?
Cheers,
Paul
I think your challenge would be the dosing, and how to extrapolate your results to known clinical cases. As you know, Sunitinib is given orally and it undergoes metabolism through the liver, and being injected directly into the tumor might cause many side effects.