Hello everybody, we are working on the eradication of Helicobacter pylori and inhibition of its biofilm. We are looking for the suggestions that what compounds would be better to use against H. pylori to inhibit the quorum sensing.
It seems that H. pylori is using a QS systems involving AI-2. So, you can look for AI-2 inhibitors--there are several compounds (lactonases, acylases, etc.). Also check this paper:
Identification of AI-2 Quorum Sensing Inhibitors in Vibrio harveyi Through Structure-Based Virtual Screening
Enzymes like lactonases, acylases which target the AHLs, various oxidoreductases, use of antibiotics, synthetic molecules that sequester the signal can be used. (Interference With Quorum-Sensing Signal Biosynthesis as a Promising Therapeutic Strategy Against Multidrug-Resistant Pathogens by Martinez et al., 2019)
Also some methanol extracts of roots of Albiza schimperiana (ASRM), Solanum torvum and petroleum ether extract of seed of Justica schimperiana (JSSP) and many more have been used and good results have been seen.
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