I have studied different SNPs (20) on different chromosome (3). I would like to know if I have epistasis interactions in two different groups (casa and controls). I'm looking for a free software that runs on win xp. Can someone help me?
You can try EIP: Epistatic Interaction Package for R (Version 1.0) at "http://cran.r-project.org/web/packages/cape".
Ciao Michele, la cosa migliore nella mia esperienza e' utilizzare MDR o GMDR. Comunque, ti suggerisco di testare anche l'epistasi tramite regressione logistica. Se hai bisogno di una mano non esitare a contattarmi.
Multifunctionality and homeostasis. Regularirites of the organism functioning, important for maintenance of homeostasis
V. A. Kotolupov, V. F. Levchenko
The Multifactor Dimensionality Reduction (MDR) software is definitely something you should try - it is designed to specifically detect epistatic interactions. And you will be able to run it on your computer: http://www.multifactordimensionalityreduction.org/
To start:
http://www.ncbi.nlm.nih.gov/pubmed/23756907
To have an overview:
http://www.ncbi.nlm.nih.gov/pubmed?term=(%22Epistasis%2C+Genetic%22%5BMesh%5D)+AND+%22Software%22%5BMesh%5D
Can we add covariates into EIP: Epistatic Interaction Package for R (Version 1.0) ? If not, is there any other software that we can use to adjust covariates for epistasis interactions? Thanks.
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