I'm looking for a human cell-line which expresses PD-L1 (could also be inducable) and MHC-II, I already checked ATCC and other sites, but couldn't find anything... I'd be glad about any information, thanks in advance :)
MHC Class II is present on antigen presenting cells. A cell line with PD-L1 and MHC-II will be mostly a macrophage cell line or a B-cell lymphoma cell line.
You can check these cell lines for the expression of both .
RAW, Ramos, Daudi, SU-DHL-4, and SU-DHL-6
May I suggest you some papers?
Clin Cancer Res. 2014 Jul 1;20(13):3446-57. doi: 10.1158/1078-0432.CCR-13-2797.
Effects of MAPK and PI3K pathways on PD-L1 expression in melanoma.
PLoS One. 2015; 10(4): e0123410. Published online 2015 Apr 6. doi: 10.1371/journal.pone.0123410 PMCID: PMC4386825
Inducible but Not Constitutive Expression of PD-L1 in Human Melanoma Cells Is Dependent on Activation of NF-κB.
J Infect Dis. 2006 Feb 1;193(3):404-12. Epub 2005 Dec 19.
Expression of programmed death-1 ligand (PD-L) 1, PD-L2, B7-H3, and inducible costimulator ligand on human respiratory tract epithelial cells and regulation by respiratory syncytial virus and type 1 and 2 cytokines.
I have also attached a poster presentation found in internet. In literature recently has been published a lot of work about PD1 and PD-L1!
Hope this could help
MHC Class II is present on antigen presenting cells. A cell line with PD-L1 and MHC-II will be mostly a macrophage cell line or a B-cell lymphoma cell line.
You can check these cell lines for the expression of both .
RAW, Ramos, Daudi, SU-DHL-4, and SU-DHL-6
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