I want to study the effect of FoxP3- CD4 T cells on immune control of tumors in mice. Does anyone know a genetic (inducible-) mouse model where I can specifically deplete either all FoxP3- CD4 T cells or specifically Th1? If not, could you think of a way to target those cells specifically? Thanks in advance!
Hi Bayerl，
We can consider the selection and strategy of this animal model in several ways.
1. FoxP3 KO/condition KO model
Cut off the path of CD4+ cell to CD4+ Foxp3+ cell. Fortunately, we have this KO model. Strain NO. T013716
2.TNFRSF3 KO model
I read some literature and found that CD4+ FOX3p+ cells have Tnfrsf3 protein on the surface. But this product is currently under development.
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