Does anyone have any recommendations or suggestions for neuronal specific crd line that is highly efficient and active?

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Benjamin Rost

You do not need high expression, but specificity. There is a good CamK2-Cre line that expresses in glutamatergic cells (Casanova et al.).

Hamdan Hamdan

I meant by highly efficient is having full KO of the gene not only in few populations or upto 50% only!

Thank you

For early onset expression I would suggest the nestin-cre mice, but if you google them you will find a lot of reports on phenotypes they have. Which brain region do you want to target? Check out the Olig2-Cre mouse line as well.