I understand that at pHpKa of the amino groups, chitosan is uncharged and therefore, it precipitates (Note: here we are referring to the chitosan solution).
However, if the positively charged amino groups of chitosan (at pH
Ava, your assumption is correct, chitosan and alginate form a very stable complex at neutral pH, read by example the work of Baysal et.al. : https://www.researchgate.net/publication/236690788_ChitosanAlginate_Crosslinked_Hydrogels_Preparation_Characterization_and_Application_for_Cell_Growth_Purposes
Article Chitosan/Alginate Crosslinked Hydrogels: Preparation, Charac...
Dear Colleague,
Using chitosan as a scaffold for inner organ repair, I can say that the degradation of this material depends indeed on the pH (acidity increases degradation processes) ut also on the molecukar configuration of chitosan and the configuration of the product ( porosity compactness and so on). So, to be sure you can have controls: chitosan gel on which you drop different pH saline (or something other) miùicring the future cultures ).
You may obtain more details contacting the firms "Medovent" (Germany) or "Kitozyme" (Belgium).
Good luck.
V.Coulic
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