probably healthy style of life since birth .

Dear Vice-Rector of Research Dr. Normakhamatov!

You spotted a highly relevant point. Humans might slowly toward the future able to develop better immune - resistance with healthier lifestyles, but the more rampage COVID-19 becomes and the more dynamically it can spread out all over the globe the less likely this immune - resistance would develop due to new emerging mutations and climate change:

1) Wagner Gouvêa dos Santos (2021). Impact of virus genetic variability and host immunity for the success of COVID-19 vaccines, Biomedicine & Pharmacotherapy

Volume 136, April 2021, Citation: "Even if COVID-19 may be brought under control in the near future, unexpected outbreaks and development of SARS-CoV-2 resistant to treatments or even vaccines are highly possible due to new mutations."Open access:Article Impact of virus genetic variability and host immunity for th...

2) Gorji, S., Gorji, A. COVID-19 pandemic: the possible influence of the long-term ignorance about climate change. Environ Sci Pollut Res (2021). https://doi.org/10.1007/s11356-020-12167-z Citation: "Multiple lines of evidence suggest that the large-scale and rapid environmental changes in the last few decades may be implicated in the emergence of COVID-19 pandemic by increasing the potential risk of the occurrence and the spread of zoonotic diseases, worsening food security, and weakening the human immune system. As we are facing progressive climatic change, a failure to act accordingly could inevitably lead to further, more frequent confrontations with newly emerging diseases.Open access:

Article COVID-19 pandemic: the possible influence of the long-term i...

Yours sincerely, Bulcsu Szekely

A very good question, however currently I don't know of any such golden rules for COVID-19.

Dear Ozodbek Abduraimov

I much liked Dr. Bulcsu Szekely opinion and that is true. Especially, after thinking about the problem what is written in these research papers I'm wondering who's really to blame in the current situation

Nodirali S. Normakhamatov , thoughtful query. There is lot of interplay between immune response & Covid infection and also autoimmune disorders and Covid infection.

The disease course in both (autoimmune disorders and Covid infection) involve a good deal of immune reactions. Also, the presence of autoantibodies in both indicates the evidence of the above sequel. Covid can tilt and distort the delicate balance of 'self-tolerance and trigger autoimmune responses through cross-reactivity with host cells'. [Curr Opin Rheumatol. 2021 Mar 1;33(2):155-162]

Furthermore, 'transient immunosuppression of innate and acquired immunity after Covid, leads to a loss of self-tolerance to self-antigens, and a form of inappropriate immune reconstitution in individuals with predisposing conditions of autoimmunity'. The so called severe inflammatory response or cytokine storm is a well recognised version in the spectrum of Covid.

[Med Hypotheses. 2020 Dec; 145: 110345.]