After years of pumping out extra red blood cells because of polycythamia bone marrow bacome so filled with scar tissue that it can not make enough blood cells to meet the need of the body ،this can lead to acute leukemia
Polycythemia vera can move to acute leukemia directly or after transformation into myelosplastic syndrome. Frequency is low (2-3%) but increases by up to 10% in patients treated with cytotoxic agents
Polycythemia vera is a type of blood cancer. It causes your bone marrow to make too many red blood cells. These excess cells thicken your blood, slowing its flow, which may cause serious problems, such as blood clots.