There is a recent study by John Osborn that demonstrate that if you use an alzet pump for delivering angiotensin you get a lot variability in your blood pressure readouts as compared to new technology pump such I-precio or tethered.
What is your opinion on that?
Dear Stefano
Judging from the article it seems as if the osmotic pump shows variations in the infusion rate, which could account for some of the variations.
Otherwise I have no explanation
I did not use infusion pumps, but I worked with subcutaneous pellets that release drugs for a pre-specified time. I used 21-days pellets filled with fluorouracil. They worked very well, even if they pasted around 17 days. During this time we observed plasma variations in drug concentrations linked to a circadian rhythm similar to that observed in humans.These pellets can be customised and "filled" with almost any drug.
Concerning Alzet pumps they are available since many years, and I am surprised to read that they are not reliable.
Usually all the infusion pumps are periodically calibrated and the variation can be less than 2%. Having said that, for a given application if the infusion time is less than, say 3 hrs, the variation can be +/- 3.6 min. that is not a significant variation. However if the infusion time is more than 12 hrs, hope you can imagine the large variation that could lead a significant difference in dosage administration.
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