We cannot imagine the existence of classical and modern physics without Newton's second law in its general form.

Newton's second law is a hypothesis of universal law that does not need mathematical proof.

It is inherent in almost all theories of physics such as Hamiltonian and Lagrangian mechanics, statistical mechanics, thermodynamics, Einstein's relativity and even the QM Schrödinger equation.

The famous Potential plus Kinetic law of conservation of mechanical energy, inherent in most formulas of QM and classical mechanics, is a form of Newton's law.

We would like to see a rigorous proof of the famous E = m c ^ 2 without Newton's second law. [1].

The unanswered question arises:

Can Schrödinger's PDE replace Newton's law of motion?

1-Quora Q/A, Does Newton's law of motion agree with the special theory of relativity?

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