Quantum dots (QDs) is growing interest for biomedical applications. At the same time, many scientists are convinced that QDs will never be used for treating patients because of their potential toxicity. Looking forward to get expert opinion and some references.
Dear Zahan as you have mentioned above, because of their significant toxicity to human their trials must be limited to the diagnostic kits and chips rather than to direct use in the human body.
Hi, dear Kudrat, I have just been researching this and suggest the following articles and hope you find it useful.
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Article Mitigating the Cytotoxicity of Graphene Quantum Dots and Enh...
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Article Glowing Graphene Quantum Dots and Carbon Dots: Properties, S...
Article The in vitro and in vivo toxicity of graphene quantum dots
Article A Near Infrared Graphene Quantum Dots-Based Two-Photon Nanop...
DOI: 10.1002/ppsc.201400219
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Article The toxicity of graphene quantum dots
Article Reinforcing nanomedicine using graphene family nanomaterials
Chapter Carbon Nanomaterials for Nanomedicine
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Article Synthesis of Strongly Fluorescent Graphene Quantum Dots by C...
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Article Synthesis of Strongly Fluorescent Graphene Quantum Dots by C...
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Thank you very much Behzad Behnam Farrokhfar Valizadeh Harzand . Actually I need few more information about pre-clinical and clinical experiment of QDs. Stay safe and fine
I agree that QDs may never find a path to the clinic but rather find feet in the flow cytometry (assays and medical devices), and LED screens, etc. Instead I can recommend looking into Cornell dots or CDots which are being translated to the clinic to my knowledge.
https://ferdinandkohle.com/more
I certainly understand that these are two different materials. However, I thought this could be a hint.
Best
The paper below is a better source:
https://stm.sciencemag.org/content/6/260/260ra149.abstract
Thank you very much Fatemeh Ostadhossein . A huge number of articles is publishing every year on biomedical applications of QDs without clinical trials. Anyway thanks again for your hints. Its really helpful.
Sure. It is probably the fact that the in vitro results are not convincing enough to back up the requirements of a full blown clinical trial. There are several stringent requirements which should be met before a nanoparticle can reach even phase I trial. However, maybe there is something I am missing. You can still check on
https://clinicaltrials.gov/
To find out if there is any trials in progress at least in US. Best wishes.
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