Hi Dr.Shankhwar,

If 3D porous architecture is something you desire and not necessarily fibre, an alternative to electrospinning might be a combination of solvent casting/salt leaching. Briefly, you need to dissolve the shape memory polymer (SMP) in a solvent along with addition of some salt. You can spread the solution on some petridish etc. and let the solvent evaporate leaving behind a film of SMP. Then you wash to remove the salt which creates the porous architecture. You can look more into this technique of salt leaching to attain controlled pore network.

As far as characterizations of SMPs is concerned, you can take a look at this article which looks into properties of SMP prepared from polycaprolactone-diol, which is also a polyester like PLA and is biodegradable. They have performed/checked Dynamic mechanical analysis (Storage modulus v/s Temperature), shape memory behavior (Shape recovery ratio %) etc.

DOI: 10.1002/app.47055

Hope that helps!

I'm not aware of a fundamental problem on spinning your system, that would make it impossible to spin.

Wendelin Jan Stark and Aldo R. Boccaccini have some publications in this area with TCP and bioglass. Maybe you will find a good staring point in their work, e.g. see DOI: 10.1002/jbm.b.30878 and its following publications with PLGA and up to 40% particles.

Dear Dr Nisha Shankhwar ,

If you want to make 3D structured mesh from 2D electrospun mat, it is also possible by using modified gas-foamed technique which was reported recently by Joshi et al. (https://doi.org/10.1016/j.cej.2015.03.121). As-fabricated mesh shows improved cellular activities. However, 3D cellular growth throughout the mesh is still remained challenging. I guess this would help you little. comments from other researchers are helpful for your other questions.