Naeem,

I am not an expert, but I believe adult cynomolgus monkeys have been used in the Ophthalmology literature as a valid model for anterior segment ischemia after strabismus surgery.  I've attached two abstracts from PubMed.

Best wishes,

R. Gary Lane

1. Ophthalmology. 1990 Apr;97(4):456-61.

A primate model of anterior segment ischemia after strabismus surgery. The role

of the conjunctival circulation.

Fishman PH(1), Repka MX, Green WR, D'Anna SA, Guyton DL.

Author information:

(1)Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine,

Baltimore, MD.

Fornix conjunctival incisions in strabismus surgery may provide partial

protection against anterior segment ischemia by preserving the perilimbal

conjunctival-Tenon's circulation, which is disrupted with limbal conjunctival

incisions. Six adult cynomolgus monkeys underwent tenotomies of three or four

rectus muscles by making limbal conjunctival incisions in one eye and fornix

incisions in the other. Iris fluorescein angiography and slit-lamp biomicroscopy

were used to monitor changes. The eyes that had limbal incisions exhibited more

severe anterior segment ischemic changes than the eyes that had fornix incisions

in every instance of four rectus muscle surgery.

PMID: 2326023 [PubMed - indexed for MEDLINE]

2. Ophthalmology. 1987 Oct;94(10):1258-71.

Anterior segment ischemia after recession of various recti. An experimental

study.

Virdi PS(1), Hayreh SS.

Author information:

(1)Department of Ophthalmology, University of Iowa, Iowa City.

In 40 normal adult cynomolgus monkey eyes, recession of various recti in

different combinations was done to evaluate their effects on the anterior

segment. These procedures were done as primary, secondary, tertiary, and fourth

procedures (each separated by several weeks or months), ultimately involving all

four recti in the eyes. In 11 eyes, posterior ciliary arteries (PCAs) were

occluded to determine its effects on the anterior segment. All eyes were examined

by slit lamp, color photography, and fluorescein angiography of the anterior

segment, and tonometry, before surgery and serially thereafter during the

follow-up period. These studies showed that recession of two or three recti

simultaneously in different combinations produced no serious permanent anterior

segment changes, although initially in some of the eyes there was transient

mild-to-moderate anterior segment ischemia. Recession of four recti

simultaneously as a primary procedure produced serious permanent ocular and

anterior segment changes; however, when this was done as a secondary or tertiary

procedure after previous recessions of three or four recti, anterior segment

changes were much fewer and milder than when it was a primary procedure.

Occlusion of all the posterior ciliary arteries in itself produced no important

changes in the anterior segment, but when combined with simultaneous recession of

both the horizontal recti, it produced serious anterior segment changes. In the

light of these findings, the pattern of arterial blood supply of the anterior

segment is discussed.

PMID: 2446229 [PubMed - indexed for MEDLINE]