1- it seems surprisingly that antibodies have stimulatory effect as in Grave's disease but how this occur ?
2 - does Grave's disease exception or there are other situations where we have stimulant antibody?
3 - is there any pharmacological efforts to develop stimulant antibody ?
Yes, there are other stimulatory antibodies as seen in some autoimmune diseases except the ersults may not be the one you expect. It is assume the antibody binding site is similar to the ligand of the receptor so it becomes stimulatory. Not able to answer the 3rd question since I am not in that field.
Antibody stimulation of hematopoietic progenitor cells was evaluated back in 1985 ...and through the years oncology research has evaluated stimulation of natural killer cells utilizing specific antibodies...2012 research evaluated this with the hopes of enhancing trastuzumab efficacy in breast cancer...and now there is a tremendous amount of focus on the mechanistic considerations of monoclonal antibodies in cancer therapy.....stay tuned for many updates in the area of Cancer Immunotherapy
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