Dhanasekaran,

You may find this review helpful:

DNA Demethylation Dynamics

Nidhi Bhutani,1,2 David M. Burns,1 and Helen M. Blau1,*

1Baxter Laboratory for Stem Cell Biology, Institute for Stem Cell Biology and Regenerative Medicine, Department of Microbiology and

Immunology, Stanford University School of Medicine, Stanford, CA 94305-5175, USA

2Present address: Department of Orthopaedic Surgery, Stanford University, Stanford, CA 94305-5341, USA

*Correspondence: [email protected]

DOI 10.1016/j.cell.2011.08.042

Dhanasekaran,

You may find this review helpful:

DNA Demethylation Dynamics

Nidhi Bhutani,1,2 David M. Burns,1 and Helen M. Blau1,*

1Baxter Laboratory for Stem Cell Biology, Institute for Stem Cell Biology and Regenerative Medicine, Department of Microbiology and

Immunology, Stanford University School of Medicine, Stanford, CA 94305-5175, USA

2Present address: Department of Orthopaedic Surgery, Stanford University, Stanford, CA 94305-5341, USA

*Correspondence: [email protected]

DOI 10.1016/j.cell.2011.08.042

In plants, they are actively removed by the de-methylating enzymes (DNA glycosylases), ROS and DEMETER

This mini review may be of some help. 'The Colorful History of Active DNA Demethylation'

remove methyl group by remove both nucleotide and -CH3 ,it mean that remove nucleotide which had methylation, new nucleotide is replaced.my teacher taught

r u talking about DNA methylation or histone methylation??

both cases respective methyl transferase available ..you can use it..

This article will help...

DNA demethylation

Alan P. Wolffe*,

Peter L. Jones, and

Paul A. Wade

Laboratory of Molecular Embryology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-5431

DNA demethylation may also occur via the TET/5-hmdc.

sending attached an excellent revision about the subject

Different putative demethylases were hypothesized, either acting by excision repair mechanisms or direct CH3 removal. My vote is for MBD2. For a review of these mechanisms, look at the two papers suggested above, at the papers by Moshe Szyf and colleagues and at the paper by my group in Journal of Nutritional Biochemistry : Fuso A, Nicolia V, Cavallaro RA, Scarpa S. DNA methylase and demethylase activities are modulated by one-carbon metabolism in Alzheimer's disease models.

J Nutr Biochem. 2011 Mar;22(3):242-51.

1. Patra A, Deb M, Dahiya R and Patra SK (2011) 5-Aza-2'-deoxycytidine stress response and apoptosis in prostate cancer. Clin Epigenet, 2: 339-348

2. Patra SK and Bettuzzi S (2009) Epigenetic DNA-(Cytosine-5-Carbon) Modifications: 5-Aza-2'-Deoxycytidine and DNA-Demethylation. Biochemistry (Moscow), 74 (6): 613-619.

3. Patra, S. K and Szyf, M. (2008) DNA methylation mediated nucleosome dynamics and oncogenic Ras signaling: insights from FAS, FASL and RASSF1A FEBS J, 275:5217-5235 [I.F. ® 3.05]

4. Patra SK (2008) Ras regulation of DNA-methylation and cancer. Exp Cell Res 314(6): 1193-1201 [I.F. ® 4.148]

5. Patra SK, Patra A, Rizi, F., Ghosh, T. C. et al. (2008) Demethylation of (cytosine-5-C-methyl) DNA and regulation of transcription in the epigenetic pathways of cancer development Cancer Metast. Rev. 27(2): 315-334 [I.F. ® 10.07]