I think that cancer is one of them.

Dear Mohannad Husain Al-Sherrawi

He is right, experimental and epidemiological evidence is scarce, although it has been related to the alteration of the circadian rhythm with:

• Decrease in factors that suppress the development of tumors and increase in body weight
• Alteration of body temperature and corticosterone secretion rhythms, changes that precede the effects on health
• Sleep disturbance clearly involved in the induction of breast cancer, experimentally demonstrated in mice

regards

Jose Luis

http://www.cell.com/current-biology/fulltext/S0960-9822(15)00677-6

Estimado Mohannad Husain Al-Sherrawi

Tiene razón, la evidencia experimental y epidemiológica es escasa, aunque se ha relacionado a la alteración del ritmo circadiano con:

• Disminución de los factores que suprimen el desarrollo de tumores y aumento del peso corporal
• Alteración de la temperatura corporal y los ritmos de secreción de corticosterona, cambios que preceden a los efectos sobre la salud
• Alteración del sueño claramente involucrada en la inducción del cáncer de mama, demostrado experimentalmente en ratones

Saludos

José Luis

http://www.cell.com/current-biology/fulltext/S0960-9822(15)00677-6

The relevant literature is associated with both shiftwork and nocturnal melatonin secretion. The most recent references that I have are:

Hakim, F., Wang, Y., Zhang, S. X., Zheng, J., Yolcu, E. S., Carreras, A., … Gozal, D. (2014). Fragmented sleep accelerates tumor growth and progression through recruitment of tumor-associated macrophages and TLR4 signaling. Cancer Research, canres.3014.2013.

Bonde, J. P. E., Hansen, J., Kolstad, H. A., Mikkelsen, S., Olsen, J. H., Blask, D. E., … Akerstedt, T. (2012). Work at night and breast cancer - report on evidence-based options for preventive actions. Scandinavian Journal of Work, Environment & Health, 38(4), 380–390.

Grundy, A., Tranmer, J., Richardson, H., Graham, C. H., & Aronson, K. J. (2011). The influence of light at night exposure on melatonin levels among Canadian rotating shift nurses. Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 20(11), 2404–2412.

Viswanathan, A., & Schernhammer, E. (2009). Circulating melatonin and the risk of breast and endometrial cancer in women. Cancer Letters, 281(1), 1–7.

Dear James C. Miller

According to its excellent update on the subject, particularly regarding the greater risk to develop cancer, or de facto, aggravation and metastasis of a preexisting cancer when the circadian cycle is altered, specifically, with alteration of the sleep-wake cycle.

These findings could explain in practice, the greater frequency of neoplastic diseases in doctors and nurses, especially those who work on night shifts and who rest little and sleep badly during the day.

It may be convenient to also address other chronic and degenerative conditions that develop or become exacerbated when the circadian cycle of the human being is altered.

I share the following publication that guides and informs about this, especially in the knowledge of the synchrony and desynchronization of circadian rhythms and their relationship with diseases:

http://www.medigraphic.com/pdfs/facmed/un-2007/un076e.pdf

José - Keep up the good work!

The circadian system is disrupted in a pretty large number of diseases e.g psychiatry (depression, autism..), hormone-dependent cancers (breast, ovarian, prostate; see attached papers on the profound alterations of marker rhythms in cancer)), alcoholism etc...

Causality or consequence?

For some of these diseases (Shift work and breast cancer for example) it seem that it is causal. Attached some papers on the topic

All best

Yvan - Good articles! Here's one that I never could get published. It's about the loss of growth hormone release during slow-wave sleep in early HIV infection. It might be of passing interest to you.

Research A relationship between human growth hormone and sleep cycles...

Interesting, thanks James for sending it

Best

Dear James C. Miller and Yvan Touitou

Important contributions to the topic that concerns us

It is true that most of the examples presented have a significant statistical and clinical relationship; between the imbalance of the circadian cycle and the development of a neoplasm or chronic and degenerative disease.

Therefore, I can consider them in principle as Risk Factors with a great burden for the disease; and when this occurs, a vicious circle of morbidity can be presented between the Antecedent and the Consequent, since they are mutually influenced and strengthened.

Jose Luis

Hello everyone, updated with the following information, the latest developments in relation to circadian rhythms and biological clock in humans.

The importance of understanding your daily biological rhythms. Your body clocks:

• Our natural daily rhythms are synchronized with the sun. A "master clock" in the brain receives direct input from the eyes and coordinates all the biological clocks in the body. During the day, it sends signals to other regions of the brain to produce hormones that will help you stay awake, increase your heart rate and give you energy. At night, when less light enters your eyes, it triggers the production of a hormone called melatonin. Melatonin makes you feel sleepy and helps you stay asleep.
• "Many of the functions of your body and normal daily activities, such as sleeping, waking up, eating and going to the bathroom, are modeled around this 24-hour cycle," explains Sesma.
• The "settings" of your biological clock are determined by specific genes. These adjustments can affect body temperature, blood pressure, activity level, inflammation (the protective response of your body to an injury or infection), fertility, mood and brain functions. Even the timing of health-related events can be related to your biological clocks. For example, heart attacks are more likely to occur early in the morning, when the level of a hormone called cortisol begins its daily rise.
• Circadian rhythms can influence dietary habits, digestion and metabolism (how our body uses and stores energy) as well. Researchers have discovered that eating later in the day, closer to when melatonin is released, can alter the body's natural rhythms. This can lead to an increase in body fat and weight gain, which is often associated with obesity, heart disease and diabetes.
• It has also been shown that time of day affects the effectiveness and side effects of certain medications, including those used to treat cancer.

Regards

Jose Luis

https://newsinhealth.nih.gov/2018/04/tick-tock-your-body-clocks

Article Later circadian timing of food intake is associated with inc...

Article Circadian Misalignment Augments Markers of Insulin Resistanc...

http://diabetes.diabetesjournals.org/content/63/6/1860.full-text.pdf

Recent experimental and limited clinical evidence indicate that the sleep deprivation of only 31 hours, secondary to the alteration of the sleep-wake cycle, increases in 5% the accumulation of beta-amyloid protein, which accumulates in the elderly, and with greater reason, in people of the third age and with risk of Alzheimer's.

https://www.nih.gov/news-events/nih-research-matters/sleep-deprivation-increases-alzheimers-protein

http://www.pnas.org/content/pnas/115/17/4483.full.pdf

I'm really taking notes especially from Dr. Jose Luis' comment. Thank you

Estimada Adu-Poku Achiaa

Agradezco su interés y valoración

Thanks for your interest Dear د. ساجدة طه محمود

follow

Dear Sadif Khan. I appreciate your interest

Dear Shakir Tuleab and Nour Shakir

I appreciate your opinion

Dear Ali A. Al-Homaidan

In complete agreement, many diseases are caused by changes in the circadian rhythm, one of them is Obesity and the other is Metabolic Syndrome.

regards

José Luis

Hello everyone

I comment that new results of recent research on the circadian rhythm have caught my attention. One of them is the one that indicates that the circadian rhythm is different in men than in women:

• A couple of researchers at the University of Pennsylvania have been looking at articles by researchers studying the circadian rhythm in humans and have found a pattern: There are gender differences. Seán Anderson and Garret FitzGerald have published a Perspective article in the journal Science that describes the differences they found.
• Previous research has found that humans and other animals have more than one type of body rhythm. In addition to the circadian rhythm, which regulates sleep and wakefulness, humans have rhythms that control breathing, shedding, and heart rate, to name just a few.
• The circadian rhythm is perhaps the best known because it has such an observable impact on our daily lives; it controls when we go to bed and when we wake up. It also participates in metabolism. We get more tired at certain times than at others and that is why we tend to speed up or slow down whatever we are doing.
• Anderson and FitzGerald analyzed studies involving more than 53,000 people. In doing so, they found that age and sex "substantially affect" the body's clocks. They found that women in general tend to be morning people, while men tend to be more nocturnal. They also found that women are more resistant to disruptions to their natural circadian rhythm.
• Women tend to be more active during the day, a pattern that is also common in children. However, they are less energetic than men at night. And they found that women spend more time sleeping and while they sleep they spend more time in deep slow-wave sleep than men. They were also more resistant to disturbances while sleeping. On the other hand, it was found that men were more likely to take afternoon naps.

https://medicalxpress.com/news/2020-09-circadian-rhythm-reveals-differences-men.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter

Update many problems or diseases because of them

Dear Haider Raid Talib

Very true

It is common knowledge that disturbances of the circadian sleep-wake cycle are important for maintaining physical and emotional health. It is also known that insomnia, or reversal of the sleep-wake cycle, is statistically related to metabolic disorders such as dyslipidemia, obesity and DM2.

Regarding the sleep pattern or if the sleep is restorative, this can be related to functional alterations that in the future alter the subject's coping with stressful situations and that, in the long term, could develop chronic, degenerative and neoplastic conditions.

Recently, an experiment was carried out with experimental models of sleep and stress susceptibility (mouse) in which two types of phenotype were identified. The researchers evaluated the sleep characteristics of stress-susceptible and stress-resistant mice before and after experiencing chronic social defeat stress (CSD):

a) Those susceptible to stress who showed social avoidance. Before CSD, stress-susceptible mice showed greater fragmentation of non-rapid eye movement (NREM) sleep due to a greater shift between NREM and wakefulness and a shorter average duration of NREM episodes,

b) Those who were resistant to stress

Compared to stress-resistant mice, susceptible ones showed pre-CSD sleep characteristics. Their analysis showed that the pre-CSD sleep characteristics of both mouse phenotypes predicted susceptibility to stress with more than 80% accuracy. Post-CSD.

regards

José Luis

https://www.mdlinx.com/news/study-finds-fragmented-sleep-patterns-can-predict-vulnerability-to-chronic-stress/EnPGqOucOEtPmHDWrLaZJ?show_order=4&utm_campaign=All+1%2F12%2F2021+Evening+Alert+-snippet+header&utm_medium=email&utm_source=iPost&ipost_environment=m3usainc&iqs=9z2zcacdrd1laqjut9h3nn4adnjf367pk64aik9rik8

Hi all

I now want to make a stop in our network of discussion and argumentation and recapitulate the following:

• There is no doubt that the alteration of the circadian cycle and sometimes the ultradian cycle, result in an alteration of homeostasis. Labile balance between the body's biochemistry, physiological functions, and adaptive changes of the biological system to changing context variables.
• There is a global alteration in the integrated function known as metabolism; which is everything that the organism requires in the complex biochemical-functional network to maintain the hormonal, immune, thermal, nutritional and general energy balance. In addition to all the functions of assimilation, anabolism-catabolism and elimination of waste products from the body by the characteristic eunctories.
• In all this, our body biomass, the microbiota biomass, both dermal-mucous, as well as oral and intestinal, participates in an intimate relationship. In such a way that the alteration of the intestinal microbiota has been found to be closely related to several metabolic disorders; among them: Overweight, Obesity, Metabolic Syndrome, Arterial Hypertension and Type 2 Diabetes Mellitus.
• Obviously, it must be mentioned then that metabolism and therefore changes in the intestinal microbiota, are closely related to circadian cycles.

https://www.researchgate.net/project/Theory-of-the-Microbiota-Intestine-Brain-Emotions-Axis

Hello

In the same sense of the discourse and only recapitulating; Regarding alteration in the circadian rhythm of sleep-wakefulness, more and more evidence is accumulating that working at night and sleeping part of the day and eating food also at night, significantly alters the metabolism, which results, in summary:

• Increase in body weight leading to overweight or obesity
• Trigger of disorders in glucose metabolism, emerging in the clinical horizon Metabolic Syndrome and within it, intolerance to carbohydrates or DM2 itself
• Trigger or uncontrolled systemic hypertension
• Alteration in lipid metabolism with hypercholesterolemia and hypertriglyceridemia
• Risk for ischemic heart disease, heart failure, pulmonary hypertension, and cerebral and peripheral vascular disease

As it can be seen, the health cost that the patient has to pay for altering his circadian rhythm is great; Well, apart from the poor quality of life and healthy old age, the expectation of a longer life is shortened by 10-20 years less.

Recently it has been investigated that the simple modification of the schedule in the taking of food, predominating the taking during the day and eliminating the nocturnal meals, has a greater impact in stopping or reverting the metabolic alterations; as long as the balance and quality of the different nutrients is preserved.

https://www.nih.gov/news-events/news-releases/study-finds-daytime-meals-may-reduce-health-risks-linked-night-shift-work

https://www.science.org/doi/10.1126/sciadv.abg9910

How, how are you doing after this 8 -month -old creative break

So far and recapitulating, we have found and discussed experiments and some clinical results that indicate that our life, ours and congeners, in addition to non -human animals and microbiological life, is regulated by short, long and ultra long rhythms; which have regulation, duration and feedback in special biochemical networks for each type of life and adjusted to the immediate context (niche) where they live, reproduce and evolve.

We human animals are physiologically governed by those rhythms that regulate us in the short term (moments, second), medium term (24 hours: day and night) sleep and vigil) and in the long term (days, weeks, months, stations) called ultradians .

In this regard, the functional, intricate and complex existence of biochemical networks that act from a local level (tissue or organ) to a sectoral combination or by area (digestive system, general immune system, cardiovascular, respiratory) and a central regulation and a central regulation and a central regulation cerebral (supraquiasmatic nucleus). It seems obvious, but it should be mentioned that local regulation is not enough, harmonic action is required as the execution of each musical instrument in a symphony within an orchestra; What is achieved, with the central regulation of the supraquiasmatic nucleus.

https://phys.org/news/2022-07-central-core-clock-machinery-majority.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter