Dear All,
if I understand correctly, when conducting a health risk assessment in order to calculate the number of cases of a certain incidence (e.g. ichaemic heart disease) due to changes in air pollution concentration, the relative risk (RR) has usually been derived from concentration-response functions (CRFs) in epidemiological cohort studies. Thereby the ß-coefficient was obtained wich then again can be used to estimate the number of cases.
In the literature the impact function itself is often referred to as "calculation-response function". I thought the CRFs are used to calculate the RR?
So my questions basically are:
How can "concentration-response function" be defined? Which are the derived parameters; RR, ß-coefficient oder number of cases?
Furthemore, does "exposure-response function" simply imply that the exposed population is already integrated within the CRF?
I hope my questions make sense. Thank you very much in advance for your help.
Kind regards,
Christiane Gackenholz
Firtst, a study of some defined population is made to determine the relation between the exposure measure and relative risk of some condition. This analysis of this study estimates the parameters of a statistical model .
This model can then be applied to other populations to calculate estimated number of cases from the exposure , the calculated risk for this new population ,and the population size.
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