I am afraid I do not understand clearly your question. The skewness of what data do you have in mind? Anyhow the most important element of any experimental data is repeatability and reproducibility. Once these two elements are there, then you can worry about other aspects.
i want do calibration between X variables and Y. when i calculate the skewness of Y i find a big skew might be this skew can disturb my calibration performance
so
what we should do if i find a big skewness in Y DATA ?