Hydroxychloroquine alone or with Azithromycin for COVID-19: No benefit but increased risk

No significant benefit with Hydroxychloroquine and Azithromycin either alone or in combination on in-hospital mortality in COVID-19 patients in USA. However, increased risk of prolonged QT-interval with risk of ventricular arrhythmias.

References

Association of Treatment With Hydroxychloroquine or Azithromycin With In-Hospital Mortality in Patients With COVID-19 in New York State

https://jamanetwork.com/journals/jama/fullarticle/2766117

Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19

https://www.nejm.org/doi/full/10.1056/NEJMoa2012410

Risk of QT Interval Prolongation Associated With Use of Hydroxychloroquine With or Without Concomitant Azithromycin Among Hospitalized Patients Testing

Positive for Coronavirus Disease 2019 (COVID-19).

https://www.ncbi.nlm.nih.gov/pubmed/32356863

Dear all, in Algeria the official high authorities annonces that the use of the combination Hydroxychloroquine alnd Azithromycin gave and still giving good and encouraging results. China also used with great access, groups of experts are still visiting Algeria and practicing the same drugs. My Regards

Hi;

Hydroxychloroquine has always been prescribed for the long-term treatment of inflammatory or autoimmune diseases, such as systematic lupus erythematosus, rheumatoid arthritis, juvenile idiopathic arthritis, or Sjögren's syndrome. However, it must be said that these pathologies make patients more susceptible to infections, despite possible preventive treatment.

Speculation about a preventive role for hydroxychloroquine when the drug has been administered chronically is therefore an open question. Several studies are currently underway to assess the effect of preventive treatment with hydroxychloroquine in highly exposed healthcare workers.

With my best regards

Dear Richard ;

Please see the links below for further details.

[1] https://ard.bmj.com/content/early/2020/04/24/annrheumdis-2020-217566.long

[2] https://ard.bmj.com/content/annrheumdis/79/5/667.full.pdf

[3] https://www.clinicaltrialsregister.eu/ctr-search/search?query=covid-19

With my best regards

Your comments and references answer my question Dr. Rachida. Thank you.

Dear Richard,

Scientists are to track the spread of the coronavirus in the world by using clues in its genetic code. Analysing samples collected from patients will also reveal whether the virus is mutating into new strains. Until now, there isn't a sufficient and satisfactory answer of your question!!!

With my best regards

No more hydroxychloroquine.

Chloroquine and hydroxychloroquine are a dead horse for COVID-19.

Think so dear Dr. Muhammad Yousuf