JAMA: March 19, 2020 COVID-19: Can We Expedite Treatment? Gary Ordog, MD, DABMT, DABEM | County of Los Angeles, Physician Specialist, Retired The authors discuss human rights pertaining to avoiding infection during the next 18 months. We are supposed to wait while a vaccine is tested for dosing schedule. "Flattening the curve" may only prolong the inevitable infection with the virus. What are our rights to preventative and curing treatments? The most vulnerable of our population currently appear to be older and medically compromised individuals. Also, the most severely ill will require ventilators, ICU beds and critical care staff, and all are currently utilized to capacity, resulting in an increasing number of newsworthy disasters already. I suggest that prophylaxis and treatment should be made available, as a medical right, in this time of impending catastrophe. Treatments that have not had time to advance to final approval may be beneficial for saving life or limb, with those patients on the exponential end of " the curve" probably glad to sign a 'waiver of liability.' As far as prophylaxis and treatment, I refer first to the vaccines that are being tested correctly and for dosage. With a century of vaccine research, I think they have a pretty good estimate of the required dose. Can we not ramp up production and start giving it to the most vulnerable, at least? Secondly, there are currently thousands of patients who have recovered from COVID-19, can these not be a source of gamma globulin for the more serious ill, at least? Stem cell lines are another possible therapy. Thirdly, there are various antiviral drugs which are safe and possibly effective but obviously have not had the time to be tested. For example, remdesivir appears to be effective against other Corona viruses, probably would have some effect against Covid-19. Could we not ramp up production of these agents and allow our vulnerable patients to have access to them, when otherwise it looks like high mortality and morbidity, with our only treatment available being "social distancing?" Thank you for allowing me to make these comments. GJO

Agree 100% with this theory and possibly supplementation with L-arginine, arginine alpha ketoglutarate and citrulline malate

https://clinicaltrials.gov/ct2/show/NCT02943161 - anyone know the progress of this pilot study?

I agree with this treatment. It would be interesting to see how acetylcholine signalling molecule is behaving in regards to COVID 19. This may shed more light on why this idea of supplementing with L-arginine and L- citrulline maybe a good idea.

Article L-citrulline as add-on therapy to increase nitric oxide, and...

Thanks for sharing this! It would be valuable to have this paper available to download. Whatever we can do to help. Best regards

I have been producing nitric oxide naturally for many years by humming and it has 

saved me many a cold/ flu.

Please look at the below links to see that this has been researched.

Humming can increase the bodies natural ability to produce NO in the sinuses 

by up to 15 times.

https://www.ncbi.nlm.nih.gov/pubmed/16406689 https://www.ncbi.nlm.nih.gov/pubmed/12119224

What is important is to hum slowly to the end of the breath and then take a slow inhale through the nose. Ie not to gasp in through the mouth.

Slowly exhaling is also an important part of parasympathetic nervous system, important for de tressing,  which is important at this time.

Worth considering as something nurses and doctors could do to calm themselves at this time and maybe even up their own NO levels.

Best Wishes

Bernardine

Please go through the attached article..

Article Nitric Oxide Inhibits the Replication Cycle of Severe Acute ...

Interesting article to read:

This appears to be proven to work, at least for asthma and erectile dysfunction, but I have yet to see much use of it in COVID-19?? Any studies current in progress? I do hope so.

Good articles to date, thank you.