July 26, 2020: The psychological impact of COVID-19 will never be fully realized. I don't think my grandparents ever fully recovered from 1918 (or the First World War). These are some of my own feelings on the subject:

1. Hypothesis: Clinical COVID-19 infections leave the patients with various degrees of brain trauma (physiologically speaking) from hypoxia, corticosteroid administration, sedative and narcotic administration, microemboli, microthrombosis, etc.

2. Hypothesis 2: Clinical and subclinical COVID-19 causes encephalitis with encephalopathy in many cases, with the resultant neurocognitive and psychological sequelae.

3. Those patients in critical condition often have residual ICU psychosis or at least psychological sequelae, if they recover. (e.g. the result of being sedated and paralyzed and tied down on a ventilator, for a prolonged period of time.

4. The rest of society that are otherwise not infected have isolation; with its resultant anxiety, depression, loneliness, anger, etc.

5. World-wide economic shut-down leads to loss of income, leading to anxiety, depression, despair, anger, etc.

6. World-wide travel shut-down leads to further isolation, depression, anxiety, anger, etc.

7. There are probably only a few people in the world who are unaffected by the results of the COVID-19 Pandemic, in one way or another. The lasting effects on each individual will probably be life-long; as it was in my grandparents from 1918.

Stay safe and thank you for letting me speak. Gary Ordog, MD

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