Seeing as PFK,PRGS and SOD1, have a triplicated overload resulting in abherrant metabolism, could a ketone supplement be administered to down regulate the glycolytic pathways, reduce purine synthesis and "feed the brain"?
its a bit of a jump but high glycolytic activity in the blood of downs patients could be inhibitied by a ketone supplementation which could correct for the metabolic imbalance and up regulate mitochondrial functions including apoptotic pathways and greater developmental control