I think you need to first find out the solvent for Dutasteride. I think it should be either acetone, hexane or pet.ether. Grind the tablet(s) very fine and try to dissolve in the solvent. There would be some precipitate which would mainly consist of binders, light paraffin oil (needed in the granulation process in tablet making) etc.  

Dear Jai,

Thanx a lot for your answer but where is the solution for the dissolution of these tablets and the method for dissolution. I need help with the dissolution method for dutasteride tablets.

The tablet can not be dissolved. I think if you are interested in the active component than, that can be extracted seperately and the rest can be discarded.

 Dear Jai,

I'm still not  satisfied with your answer. I'm just looking for someone who can help me with the proper in-vitro dissolution method of these tablets.

Thanx a lot.

 You can search in USP  American pharmacopoeia for an official procedure. You can get the appropriate method, apparatuses, assay of the drug etc...........   

Hi! Mahmoud,

There is no official method for Dutasteride Tablets. I've checked in USP.

there is a dissolution method in FDA database

paddle ,50 rpm ,900 ml

Tier I: Dissolution Medium: 0.1 N HCI with 2% (w/v) sodium dodecyl sulfate (SDS) (900 mL) Tier II: Dissolution Medium: 0.1 N HCI with pepsin (as per USP) (450 mL) for the first 25 minutes, followed by addition of 0.1 N HCI with SDS (4% w/v) (450 mL) for the remainder of the dissolution test.

http://www.accessdata.fda.gov/scripts/cder/dissolution/dsp_getallData.cfm

I wish it could help

thanks

there is a dissolution method in FDA database

paddle ,50 rpm ,900 ml

Tier I: Dissolution Medium: 0.1 N HCI with 2% (w/v) sodium dodecyl sulfate (SDS) (900 mL) Tier II: Dissolution Medium: 0.1 N HCI with pepsin (as per USP) (450 mL) for the first 25 minutes, followed by addition of 0.1 N HCI with SDS (4% w/v) (450 mL) for the remainder of the dissolution test.

http://www.accessdata.fda.gov/scripts/cder/dissolution/dsp_getallData.cfm

I wish it could help

thanks

Dear Engy,

Thank you for your answer. I would like to inform you that this method provided in the FDA database is for Dutasteride Softgels and not for tablets. I've already tried this method before and it did not work for my tablets.

Regards,

Abhishek