It has been reported that Countries with mandatory policies to vaccinate against tuberculosis register fewer coronavirus infections and deaths than countries that don’t have those policies. Another important observation is that; Favipiravir, that is very recently reported to be effective therapy for coronavirus infections, is structurally closely related to Pyrazinamide. Pyrazinamide is the third most important drug (following isoniazid and rifampicin) in the chemotherapy of tuberculosis. What do you think?
Hajjaj Abdu-Allah
There is still controversy about the effect of drugs on COVID-19, especially the repurposed one as those described here. The following paper found the lack of any activity of flavivirapir on CVID-19 in vitro even at high concentration of 100 uM.
https://pubmed.ncbi.nlm.nih.gov/32251767/?from_term=Flavipiravir&from_sort=date&from_pos=3&from_exact_term=favipiravir
Please check the following references:
https://economictimes.indiatimes.com/news/science/us-scientists-link-bcg-vaccination-with-fewer-covid-19-cases-indian-scientists-hopeful-but-cautious/articleshow/74931591.cms?from=mdr
https://www.japantimes.co.jp/news/2020/04/09/world/science-health-world/fewer-coronavirus-deaths-seen-countries-mandate-tuberculosis-vaccine/#.XpCtX8j7RPZ
https://www.theguardian.com/world/2020/mar/18/japanese-flu-drug-clearly-effective-in-treating-coronavirus-says-china
· Liying Dong, Shasha Hu, Jianjun Gao, Discovering Drugs to Treat Coronavirus Disease 2019 (COVID-19), Drug Discov Ther 14 (1), 58-60, 2020. DOI: 10.5582/ddt.2020.01012
https://thehill.com/changing-america/well-being/prevention-cures/491829-us-trial-of-japanese-flu-drug-to-treat
https://www.japantimes.co.jp/news/2020/04/07/national/science-health/coronavirus-japan-avigan-20-nations-free/#.XpDix8j7RPY
Good point. I asked a variation on your question in my section. Thank you.
I found this clinical trial in Egypt
but no information about its location and who is perfroming it
https://clinicaltrials.gov/ct2/show/NCT04350931?cond=covid&phase=2&draw=5&rank=36
but no information about its location and who is performing it
very attractive ideas.
Remarkably, the repositioning drugs that are currently utilized for treatment of COVID-19 either have pyrazine, quinoline s or adenine moieties. Modification of these structures by incorporation of halogens and hydrophobic parts at the vacant positions of the heterocycles will lead to promising candidates as antiviral agents that might be used to fight against COVID-19.