I have 5, 12 v dc vaccum pumps. The vaccum pressure they can maximum achieve is -450 mm oh hg. can i connect them in series to get a vaccum of -750 mm of hg. I calculated this according to the compression ratio.
It's unlikely to work this way - every pump operates optimally within a certain range of inlet pressures. Some designs are more sensitive to pressure than others (turbo pumps: I'm looking at you...) and simple diaphragm pumps (which I suspect might be yours) are less sensitive to inlet pressure.
(they'll shift the contents of their closed volume pretty much indepedently of its pressure)
These pumps likely have a (one way) check valve at the outlet which is actuated upon compression of the diaphragm. On the evacuation portion of the cycle the valve closes. As such there is a minimum pressure differential required for pumping action to occur. Adding a second pumping stage should result in lower base pressure at the inlet, however one reaches a point of diminishing returns adding additional series stages. Ultimately the inlet pressure will be limited by reverse leakage of the check valve and diaphragm seals.