While doing statistical data analysis I have also encountered extremely low p-values.. why is this a problem? A low p-value means high significance for whatever hypothesis you have constructed.

Hello,

As Ben Napier already answered, a low p-value means significant results of the analysis. It should be reported as p

I understand low p values means the test is significant, but for this case it is extremely low to tune of 1.74020337167983E-60 , 1.3259484055519E-28 .

Anyway ,I got the reason for that...some sequences were having frame shift mutation , resulting to false positive outputs.

I always come across branch pvalue 0, no sites come out.