Who's the strongest?
what are the units that can express the role in immune reaction?
who can compare between them in a way that makes me able to the use
to be clear in what i teach
A basic tenant of immunology is that the TCR is signal 1 (nothing can happened without it), co stimulatory molecules (eg CD28, ICOS) are signal 2 and cytokines are sometimes refered as signal 3. Thus, signal 1+2+3>signal 1+2>signal 1
That is especially true in vitro where the "units" (not sure what you are thinking of) are measured with a CFSE dye (or alike) that dilute in daughter cells. In vivo, the most common outputs of these are T cell activation measured by acquisition of CD44 , or CD69 (early), loss of CD62L and acquisition of Ki67. Cytokine production ex vivo is also a good indicator of T cell activation (IFNG, TNF and IL2 being the most common ones and 3 are better than one). Hope that helps
doctor Gilles Marodon very thanks to you firstly..especially for simpling the sentence that is used.
- Badges
- Science topic