I am trying to find the list of cells that content endosomal TLRs (TLR3,7,8 and9). Are these TLRs expressed all over the body or there are very specific cells that expresses these TLRs?
Any input is appreciated. Any reading material to find the answer is appreciated.
Thank you.
Hi,
this might be a good start for your search (check Figure 1): http://www.jimmunol.org/content/168/2/554.
Best,
Nicolas
They are not. The expression of endosomal TLRs only has sense in the case of phagocytic cells. For example, in humans the expression of TLR9 is restricted to B lymphocytes and plasmocytoidal dendritic cells. The later cell type also the most abundantly express other endosomal TLRs.
Szczepan, thank you for replying to the question. Do you have any reading material that supports your answer? I will highly appreciate if you could share here. Thank you again.