If you need a lot of pcr product then it is usually better to run many small reactions. A good pcr machine moves very quickly between the 3 temperatures of a pcr cycle so as to stop template reannealing at the hot end and minimise the enzyme working badly at the low end of the temperatures. PCR machines are calibrated for a small range of volumes and very large volumes are prone to temperature overshoot due to the large volume and thermal inertia. So cooling to 50c may overshoot to 47 then readjust to 50 but inappropriate primer binding has alrady taken place at 47 and spurious pcr products will be produced. At the top end the temperature will overshoot by a few degrees and shorten the life of the polymerase.

It will be possible to scale up but you will need faster heating (microwave?) and cooling and very different eqipment, Using a strand displacement polymerase at a single extension temperature or rolling circle amplification are probably easier to scale up or cloning and plasmid purification could be considered

Polymeric chain reactions refer to chemical reactions that involve the growth of polymer chains through repetitive monomer addition. These reactions often follow a chain-growth mechanism, where a reactive species (such as a free radical) adds to a monomer, generating another reactive species that can continue the chain propagation.

The scalability of polymeric chain reactions depends on several factors, including reaction kinetics, heat and mass transfer considerations, process control, and safety considerations. While it is often feasible to translate lab-scale reactions to industrial-scale production, certain challenges need to be addressed.

Feasibility of translating lab-scale reactions to industrial-scale production depends on various factors specific to the reaction system and process. While some polymeric chain reactions can be scaled up successfully, others may face challenges that require modifications in reaction conditions, reactor design, and process control strategies. Pilot studies and thorough process development are often necessary to bridge the gap between lab-scale and industrial-scale production.

Sesha Bhavana Jagarlapudi Sesha, links below offer additional information to that of Paul and Sakshi :

1)__ Polymerization Reaction (search for scale)

https://chemed.chem.purdue.edu/genchem/topicreview/bp/1polymer/reactions.html

2)__ Chemical kinetic mechanisms and scaling of two-dimensional polymers via irreversible solution-phase reactions

https://pubs.aip.org/aip/jcp/article/154/19/194901/565941/Chemical-kinetic-mechanisms-and-scaling-of-two

3)__ Scalable synthesis of sequence-defined, unimolecular macromolecules by Flow-IEG

https://www.pnas.org/doi/10.1073/pnas.1508599112

We can use them as a pre-diagnostic test for prostate cancer. Kits can be crafted in industries.

PCR could be scaled to idustrial-scale, look for thin film flow reactors. But that approach will be extremely expensive.