Under the mannich reaction, after the initial amine-formaldehyde reaction, could xylene act as a substrate to stabilize the reaction if the reaction does not stabilize during or prior to dehydration and clearing? In synthetic chemistry, amine-formaldehyde reaction products can attack ring structures, is this possible under the FFPE processing conditions?
Madhukar Baburao Deshmukh
Mannich reaction during formalin fixation you need a substrate having active methylene group like actopphenone & not xylene.
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