I would like to attach DNA to AFM tip and image it using SEM to check if coating was done properly. I couldn't find any papers that show SEM images of DNA. I would like to know the protocol to do the same.
Please let me know if anybody finds references.
http://www.dailymail.co.uk/sciencetech/article-2240913/DNAs-double-helix-pictured-time-Researchers-hope-new-technique-reveal-molecule-works.html
http://www.pnas.org/content/93/11/5341.full.pdf
Dear Vladimir and Gintautas,
Thank you very much for providing me the references.
Are there any references within last ten years?
What could be the reason for not imaging DNA using SEM?
"What could be the reason for not imaging DNA using SEM?"
In general, TEM and AFM have higher resolution and they are more suitable tools for such tasks. In addition, an AFM can operate in liquid and makes it possible to study mechanical properties of molecules at physiological conditions.
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