I have seen its application in many papers on modified release tablets but i got a reviewer's response on my paper that Hixon-crowel is only applicable to microspheres.
Hi,
Hixson Crowell's cube root equation is a mathematical model used to describe powder dissolution or drug release from specific formulations. The shape (drug particles , drug dosage form...) is spherical and size will decrease as the system dissolves. For drug dosage forms this model best describes release from erodible matrix which are sustained release tablets. However, it can also apply to polymeric erodible nanoparticles or microspheres. From these spherical sustained release dosage forms, drug release depends on drug diffusion inside the matrix and polymeric matrix erosion following polymer degradation. If the matrix erosion is very slow, drug release rate will mainly be governed by drug diffusion from the dosage form, different models might be more suitable to describe drug release such as Higuchi's model (fraction of drug released proportional to the square root time) or Korsmeyer-Peppas's model. Try to modelize your drug release according to several different mathematical model to see which one best describes the process for your dosage form.
Best regards,
Thanks Dr Gilles Dollo for the detailed answer. I have applied zero order, first order, Higuchi's model, Hixson Crowell's model and korsmeyer peppas models on my data however, release was best fitted into korsmeyer peppas model because of the high R value but the reviewer asked me that why you applied Hixson crowell model on sustained release system as it is only for microspheres, thats why i asked here to reconfirm it because I have seen in many papers on sustained release Hixson crowell's model is applied.
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