We can formulate combination of drugs provided if they are incompatible to each other and also with the remaining ingredients.

SEDDS which are isotropic mixtures of oils, surfactants, solvents and co-solvents/surfactants, can be used for the design of formulations in order to improve the oral absorption of highly lipophilic drug compounds.

This formulations can be orally administered in soft or hard gelatin capsules and form fine relatively stable oil-in-water (o/w) emulsions upon aqueous dilution owing to the gentle agitation of the gastrointestinal fluids. The efficiency of oral absorption of the drug compound from the SEDDS depends on many formulation-related parameters, such as surfactant concentration, oil/surfactant ratio, polarity of the emulsion, droplet size and charge, all of which in essence determine the self-emulsification ability. Hence, very specific pharmaceutical excipient combinations will lead to efficient self-emulsifying systems.

Before you go for specific combinations incompatibility should be checked. And other stability aspects, drug interactions etc are also considered.

They can both be loaded within SEDDS. However, as they have porr solubility in oils, probably you will need to develop the SEDDS with a high surfactant content and with the presence of solvents (such as ethanol)