Hello, research community, I would like to clarify a question with you. Is there any study hypothesizing that the prolonged activation of glucose-6-phosphatase (G6Pase) during fasting exercise may, in the long term, overload pancreatic beta cells and increase the risk of type 2 diabetes in individuals with insulin resistance, due to excessive glucose release by the liver?
I’ve searched extensively in databases but haven’t had any success. If you could help me with this, I would be very grateful.
Sincerely, Raquel da Franca.
Dear Raquel da Franca,
I also couldn’t find any research specifically about prolonged activation of glucose-6-phosphatase (G6Pase) during fasting exercise overloading pancreatic beta cells and increasing type 2 diabetes risk in individuals with insulin resistance. But there are some related studies on G6Pase activity in type 2 diabetes and hepatic glucose production. For example, one study found that G6Pase activity is increased in patients with type 2 diabetes, leading to higher endogenous glucose production and fasting plasma glucose levels. And some research suggests that insulin resistance can impact the relative activities of glucokinase and G6Pase, favoring glucose production over G6P storage in the liver, contributing to excessive hepatic glucose production in type 2 diabetes.
Hope this information is helpful to you.
Best regards.
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