These days I come across patients with treated cleft lip and palate for further dental treatments like restorations and orthodontic management. Most of the patients reporting are usually from lower socioeconomic strata.
Since there is no single cause responsible for any craniofacial defects like cleft lip and palate. Several Environmental factors with faulty genes transfer along with a folic acid deficiency in maternal diet during pregnancy can also result in certain congenital abnormalities.
Can there be more risk factors involved?
Are there some better avenues dealing with the prevention of such birth defects?
Have no idea about the topic, following and seems to be a research topic to fond out whats what and any relevance with socioeconomic backgrounds.
Dear Prof Amina
Excellent question about antioxidant dietary supplementation which is very true and essential.
Thank you
Yes! Please take a look at these useful RG links.
Article Maternal Diet Supplementation with Methyl Donors and Increas...
Article Prevention of Treacher Collins syndrome craniofacial anomali...
Arvind Singh Thank you so much for your valuable contribution. Your interest and zeal in contributing are quite appreciable.
Regards
Parisa Ziarati Terry Purvis
Emre Pakdemirli Many thanks for the contributions and support to the discussion.Regards
Very important question! In a recent (published in 1 October 2019) study at Uppsala University, Sweden showed that maternal treatment with antioxidants such as butylated hydroxytoluene and vitamin C and E reduced the rate of craniofacial and skeletal malformations, while treatment with vitamin E decreased the rate and severity of CHDs in rats, suggesting the involvement of reactive oxygen species (ROS). For details, please see the attachment. Thanks.
Article Say NO to ROS: Their Roles in Embryonic Heart Development an...
Ali Alwaeli
Md Rabiul Alam Many thanks to both of you.. I appreciate your interest and valuable responsesregards
Ali Alwaeli
Thank you so much for your recommendations and supportive response. Much regards and appreciations.Abbas J Jubear Thanks for your interest.Regards
Terry Purvis
many thanks for your response and for sharing an important link.my apologies for the late acknowledgement.
Regards-Amina
Ali mohamed rashed
appreciate your elaborate contribution many thanks..Ali Alwaeli
Appreciate your support and participation. regards
Thank you dear Dr.Amina Sultan for this important question....I am with you that antioxidant deitary suplement is very effective to prevent certain defects and anomalies especially if there is good observation and consultation.
Huda A Al-Sarraf Thank you dear for your useful contribution. I appreciate your interest.
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