Dear friend Nada Nasser

https://youtu.be/FyoYtmrnEoQ?si=Is4Efq1NtgaHnE_Y

This video can be very helpful to understand the solution presented here.

Thank you for raising such an intriguing question regarding the suitability of activated carbon as a stationary phase in Liquid-Solid Chromatography (LSC). I appreciate your curiosity and am excited to delve deeper into this topic with you.

When considering materials for the stationary phase in LSC, several key characteristics come to mind: high surface area, appropriate porosity, chemical stability, and the ability to facilitate selective interactions with analytes. Activated carbon is particularly notable for its extensive porosity and large surface area, which can enhance the adsorption of various compounds. These properties may allow for improved separation efficiency, especially for molecules that interact strongly with carbon surfaces through van der Waals forces or π-π interactions.

However, it is also important to consider potential limitations. The heterogeneous surface chemistry of activated carbon can sometimes lead to non-specific interactions, which might reduce selectivity compared to more tailored stationary phases. Additionally, the strong adsorption capacity could result in challenges with analyte recovery or elution.

In comparison to traditional materials used in LSC, such as silica or alumina, activated carbon does offer unique advantages in terms of surface area and the diversity of chemical interactions. It would be valuable to further investigate how these properties translate into practical performance in chromatographic applications.

I would be interested to hear your thoughts on which specific analytes or separation challenges you believe activated carbon could address most effectively. Please let me know if you would like to discuss this further or collaborate on a more detailed review.

Best regards,

Kaushik