Hi Pooriya,

I think this is a vague statement to say the least. It will be easier to answer if you would add some context (citation). Misfiring can be produced through an experimental intervention or in a pathological state and would be simply translated to not firing correctly. In other words, action potentials of the neurons are not generated as they normally would. Again what that means depends on the context, because the citation could refer to direct spike timing or encoding of information or many other parameters.

Hope this helps a little bit.

Julian

Dear Wolf-Julian

Thank you for your elegantly responding.

I faced the below statements and expression of "Dopaminergic Neurons Misfiring" was not understandable to me.

"A number of attempts have been made to explain the link between altered brain function and schizophrenia. One of the most common is the dopamine hypothesis, which attributes psychosis to the mind's faulty interpretation of the misfiring of dopaminergic neurons"

Are they giving a reference for that statement?

Yes sir. Please find the attached document.

In context of the quote "misfiring" refers to pathophysiology. the Da neurons are not firing the way they do in normal (non-schizophrenic) brains. So they are firing in a sickened or pathological way... Again as Wolf-Julian Neumann suggests this is a vague way of describing something.

To clearly make that statement and back it up one must know how Da neurons fire throughout the brain in normals.and Da neurons are not just in the subsantia nigra, nor just in the caudate. one would have to know the normal fring pattern in many places under many condtions, and then examine those same neurons in the "Schizophrenic" brain fire.

So in the end it is just a shorhand glib way of saying that schizophrenic brains may have a sickened Da system that doesen't quite fire right...