In experiments to detect effects of GPCR agonists on barrier function of endothelial cells, different agonists can have different sodium contents. In my case, I use the agonists at different levels because they have different affinities to the receptor. Therefore, results can be confounded by different sodium contents of the agonists. Can you share your experience with this problem? If you share any article that discuss this problem would be very beneficial.
Jordan R. Yaron
It's a reasonable concern. The best way to determine this is to have vehicle controls which also account for salt content changes caused by your agonists.
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