Hello
Nitrooxy group (nitrate esters) is used in the preparation of vasodilators.The use of silver nitrate to convert alkyl halides to nitrate esters is very common.
A. McKillop & M. E. Ford used mercury nitrate in organic media, but not repeated by someone else.
Can other nitrate salts be used to convert halides to nitrate esters?
Thanks all.
Dear Mut Mut for the preparation of alkyl nitrates from inorganic nitrates and alkyl halide, silver nitrate is certainly the reagent of choice. This is because the by-product AgCl is quantitatively formed as a precipitate. Mercury nitrate is not recommended due to the high toxicity of mercury. To the best of my knowledge, alkali metal nitrates (NaNO3, KNO3) do not react directly with alkyl halides under formation of the alkyl nitrates. I found one article in the literature that at least comes close to this. It describes the synthesis of alkyl nitrates from the corresponding alcohols, potassium nitrate and BF3.
Article Convenient Preparation of Alkyl Nitrates Free of Nitrites wi...
Dear Mut Mut you're very welcoome. Are you planning to try this reaction out in the laboratory? I yes, please let us know if it worked and be very careful with the resulting alkyl nitrates as they can be explosive. If you need any further information, please let me now.
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