Recently I was wondering can Diethylether can be an extraction solvent for antioxidant study? As it is used as a solvent for oils and fats. Could someone use this for phenolic acids extraction?
Did anyone get any suggestions regarding this?
Yes you can use diethyl ether for phenolics extraction.
For further information you can look these articles:
Article Survey of solvents for the extraction of grape seed phenolics
Article HPLC study of extraction of phenolic compounds
Generally, the solubility of the phenolics depends on their structure, particularly the polarity and the interaction between phenolics and other plant components such as protein and carbohydrates. As per the solvent, the polarity of the solvent is an important factor. However, the extraction yield and the antioxidant activity of the extracts can be vary with the type of solvent.
As you have mentioned, diethyl ether can also be used as a solvent for phenolic extraction.
Hope the following articles will be useful for you,
Article Influence of the solvents on the extraction of major phenoli...
https://www.scielo.br/j/cta/a/wGHdYqC6WpSgcSkHqq4khKB/?lang=en&format=pdf
Thank you Heshani Rathnayake and Hayri Üstün for your valuable responses. I'm looking forward to that in the articles you suggested.
Dear Ashwani Punia
Although your question is not clear, I can answer based on my understanding. Diethylether can be used as an extraction solvent. If you design to accomplish an antioxidant study for the extracted product, simply evaporated the solvent and re-dissolve the products with ethylacetate.
All the best for you
Also, Thank you so much for Professor Frank T. Edelmann for sharing this valuable question.
Dear Ashwani,
for extraction of phenolic acids from plants, diethyl ether is certainly among the useful solvents. A particular advantage of diethyl ether is its low boiling point, so that (as already mentioned by Yasser Fakri Mustafa) the solvent is easily evaporated after the extraction. However, don't forget the very high flammability of diethyl ether when working with this solvent!
Besides phenolic acids, many plants contain different phenolic components. Thus in order to extract all of them, it makes sense to carry out the extraction with solvents of different polarity such as hexane, ethyl acetate, and methanol (in this order).
For comprehensive information about the various extraction techniques, please have a look at the following book chapter:
Extraction Techniques of Phenolic Compounds from Plants
Chapter Extraction Techniques of Phenolic Compounds from Plants
Fortunately this book chapter has been posted as public full text on RG, so that you can freely download it as pdf file and print it out if needed.
Good luck with your research work and best wishes, Frank Edelmann
I totally agree with Dr. Yasser Fakri Mustafa & Prof Frank T. Edelmann about the extraction technique they mentioned regarding the diethyl ether solvent.
Good luck Ashwani Punia for this study and go ahead.
Becasue of the low boiling point it is not recommended for analytical extraction (the volume may change if not properly handled, changing the concentrations). Moreover it has to be handled very carefully because of its flammability.
Dear Ashwani,
your question is not clear. you can use diethylether for phenolics extraction solvent. diethyl ether is its low boiling point, So I agree with Dr. Yasser Fakri Mustafa about the extraction technique they mentioned regarding to the diethylether solvent.
All the best for you
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